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OMP E is another protein that little is understood about. Again it shows similar morphology to a porin, OMP F found in E. Coli . However, further research must be done to determine significance.

Electron micrograph of strain B-88-152 showing pili. From: {20}

The virulence of pili in M. catarrhalis is a topic of debate. In a study of virulence of pili presenting strains versus non pili presenting strains, at 6 hours after colonization, the acute ostitis media score for pili strains was significantly higher than that of non pili. However, at 24-72 hours, the scores for non pili were significantly higher than pili [21] . This seems to indicate that the initial onset of symptoms from pili forming strains is much more rapid than non pili. However, non pili strands seem to incur a more delayed, drawn out response.

M. catarrhalis has two primary mechanisms that allow it to derive iron from its host, which also might have a function in protecting the organism from the anti bacterial qualities of blood serum. These are transferrin-binding proteins and lactoferrin-binding proteins. They are generally expressed in higher frequency when iron becomes scarce and, because they steal iron from the host, can be very damaging.

Two subunits TbpA and TbpB are involved in binding transferrin to acquire iron for the bacterial cell in the first mechanism. Studies of these proteins have found that TbpA can function in binding transferrin and free iron independently of TbpA, but not vice versa Modern Tee Birch Top by VIDA VIDA Pay With Visa v0XiT
. Additionally, in serum, TbpB illicits an immune response through Ig secretion, but not TbpA. This response seems to be directed towards complement activation against the pathogen Silver Multicoloured Studded Sliders 3 / METALLIC I Saw It First Outlet Manchester Great Sale 2018 Unisex For Sale Under 50 Dollars Ebay Sale Online adVwIN4
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This is also composed of two subunits, LbpA and LbpB, which have been cloned and studied. They are shown to bind lactoferrin molecules to derive iron. Again, the B subunit seems to carry out the actual function of binding and also attracts a strong immune response. This could also be a candidate for a potential vaccine Outlet Geniue Stockist Cheap Sale Many Kinds Of Black Lace Dress With Fur Trim Sleeves 10 / BLACK I Saw It First Excellent Cheap Sale 100% Guaranteed Affordable Sale Online 6g2KsUR
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LOS is a prominent component on the surface of the pathogen. It consists of an A lipid chain linked to ketodeoxyoctulonic acid which is then linked to the inner core. The A lipid is very similar to the typical type of members of the Enterobacteriaceae family. There are also epitopes expressed which are homologous with other gram negative bacteria. LOS serotyping is used to classify strains of M. catarrhalis , the majority fit into category A, B, or C, with some minor exceptions. In a typical human immune response, there are usually antibodies present for each of the three main types, even when the infection only consists of one type [24] .

Infections induce very strong inflammatory responses which trigger secretion of IL-1β, IL-6, IL-8, and TNF-α, which cause very strong respiratory symptoms. In young children, the disease most commonly migrates from the nasopharynx to the middle ear via the Eustachian tube and causes otitis media. This is generally more mild than infection from S. pneumoniae with less fever and a lower likelihood of developing a a red bulging tympanic membrane Discount Release Dates Sale Get To Buy SHIRTS Blouses Simona Martini 9y30VCvnMZ
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Chlamydia pneumoniae , as you may have guessed by its name, is one of the main causative agents of pneumonia, and bronchitis. It has also been linked with artherosclerosis, and multiple sclerosis. Chlamydia pneumoniae is not the STD form of chlamydia most commonly known, that is Chlamydia trachomatis. Chlamydia pneumoniae was first linked to heart disease in 1988, when C. pneumoniae antibodies where identified in people with artherosclerosis. Subsequent studies have confirmed this connection, but many studies have also repudiated the connection. While it is an intriguing idea, more extensive and convincing research needs to be done. Another interesting connection of C. pneumoniae is with multiple sclerosis. No studies have confirmed this connection to date, but many patients afflicted with MS have tested positive for chlamydia in their spinal fluid. It is essential to understand that C. pneumoniae is not a sexually transmitted disease, and thus there is no connection between STDs and either artherosclerosis, or multiple sclerosis. Chlamydia trachomatis is the more well-known of the two pathogens, and causes the most common STD in the world, chalmydia, and has been linked with blindness and infertility. There are believed to be over 50 million new cases worldwide annually. The symptoms of chlamydia depend on the site of infection. It is transmitted through infected secretions, and mainly infects mucosal membranes, particularly the cervix, rectum, urethra, throat and conjunctiva (eyes). Trachoma, one of the primary causes of blindness is due to infection by Chlamydia trachomatis . It can be transmitted through eye discharge, or contact with eye-seeking flies, and causes an inflammatory reaction in the eye, which produces scar tissue on the conjuntiva. This forces the eye lid to turn inward, where eye lashes can rub the cornea, causing scarring.

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The most dangerous thing about chlamydia when transmitted sexually is that 75% of women and 50% of men are asymptomatic, and are completely unaware that they are infected. Chlamydia infection is a major cause of infertility, not only in women, but in men as well. Women are subject to pelvic inflammatory disease (PID), and ectopic pregnancy. 40% of women with chlamydia will develop PID and of that 40%, 20% will become infertile and 9% will have a potentially fatal ectopic pregnancy. Recently, research has shown that women infected with chlamydia are 3-5 times more likely to contract HIV. In men, infections often begin in the urethra, with urethritis, and can progress to the upper genital tract, causing epididymitis and prostatitis. In addition it can attach to sperm, which increases the risk of transmission to women. It has been shown that chlamydia can affect sperm health, contributing to male infertility. When infected with chlamydia, sperm show a dramatic decrease in motility, and viability.

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